X0306 4 2020-11-02 0 0001768224 Arcturus Therapeutics Holdings Inc. ARCT 0001727317 Chivukula Pad C/O ARCTURUS THERAPEUTICS HOLDINGS INC. 10628 SCIENCE CENTER DRIVE, SUITE 250 SAN DIEGO CA 92121 0 1 0 0 Chief Scientific Officer & COO Common Stock 2020-11-02 4 S 0 10000 55.28 D 702548 D The reported price is the weighted average price per share sold by the reporting person. Reflects the weighted average price of 10,000 shares of common stock of Arcturus Therapeutics Holdings Inc. sold by the Reporting Person in multiple transactions on November 2, 2020 with sale prices ranging from $53.04 to $56.80 per share. The Reporting Person undertakes to provide upon request by the U.S. Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price. The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. /s/ Ilan Katz, attorney-in-fact 2020-11-03