SCHEDULE 13G/A 0000902664-23-004108 0001603466 XXXXXXXX LIVE 1 Common Stock, par value $0.001 per share 09/30/2025 0001764974 Turnstone Biologics Corp. 90042W100 9310 ATHENA CIRCLE, SUITE 300 LA JOLLA CA 92037 Rule 13d-1(c) Point72 Asset Management, L.P. b DE 0.00 0.00 0.00 0.00 0.00 N 0 PN Point72 Capital Advisors, Inc. b DE 0.00 0.00 0.00 0.00 0.00 N 0 CO Point72 Biotech Private Investments, LLC b DE 0.00 0.00 0.00 0.00 0.00 N 0 OO Differentiated Ventures Investments, LLC b DE 0.00 0.00 0.00 0.00 0.00 N 0 OO 72 Investment Holdings, LLC b DE 0.00 0.00 0.00 0.00 0.00 N 0 OO Steven A. Cohen b X1 0.00 0.00 0.00 0.00 0.00 N 0 IN Turnstone Biologics Corp. 2200 Powell Street, Suite 310, Emeryville, California 94608 This statement is filed by: (i) Point72 Asset Management, L.P. ("Point72 Asset Management") with respect to the shares of common stock, par value $0.001 per share ("Common Stock") of Turnstone Biologics Corp. that were held by an investment fund it manages; (ii) Point72 Capital Advisors, Inc. ("Point72 Capital Advisors Inc.") with respect to the shares of Common Stock that were held by an investment fund managed by Point72 Asset Management; (iii) Point72 Biotech Private Investments, LLC ("Point72 Biotech") with respect to the shares of Common Stock of which it was the holder; (iv) Differentiated Ventures Investments, LLC ("Differentiated Ventures"), the managing member of Point72 Biotech, with respect to the shares of Common Stock that were held by Point72 Biotech; (v) 72 Investment Holdings, LLC ("72 Investment Holdings"), the sole member of Differentiated Ventures, with respect to the shares of Common Stock that were held by Point72 Biotech, and (vi) Steven A. Cohen ("Mr. Cohen") with respect to the shares of Common Stock that were beneficially owned by Point72 Asset Management, Point72 Capital Advisors Inc., Point72 Biotech, Differentiated Ventures, and 72 Investment Holdings. The address of the principal business office of Point72 Asset Management, Point72 Capital Advisors Inc., Point72 Biotech, Differentiated Ventures, 72 Investment Holdings, and Mr. Cohen is 72 Cummings Point Road, Stamford, CT 06902. Point72 Asset Management is a Delaware limited partnership. Point72 Capital Advisors Inc. is a Delaware corporation. Point72 Biotech, Differentiated Ventures, and 72 Investment Holdings are Delaware limited liability companies. Mr. Cohen is a United States citizen. Y The information required by Item 4(a) is set forth in Row 9 of the cover page for each of the Reporting Persons and is incorporated herein by reference. Such information is as of the close of business on September 30, 2025. Point72 Asset Management, Point72 Capital Advisors Inc., and Mr. Cohen own directly no shares of Common Stock. Point72 Capital Advisors Inc. is the general partner of Point72 Asset Management. Mr. Cohen controls each of Point72 Asset Management and Point72 Capital Advisors Inc. Differentiated Ventures is the managing member of Point72 Biotech and may be deemed to share beneficial ownership over the shares of Common Stock that were held by Point72 Biotech. 72 Investment Holdings is the sole member of Differentiated Ventures and may be deemed to share beneficial ownership of the shares of Common Stock of which Differentiated Ventures may have been deemed the beneficial owner. Mr. Cohen controls each of Point72 Biotech, Differentiated Ventures, and 72 Investment Holdings. 0% The information required by Item 4(c)(i) is set forth in Row 5 of the cover page for each of the Reporting Persons and is incorporated herein by reference. Such information is as of the close of business on September 30, 2025. The information required by Item 4(c)(ii) is set forth in Row 6 of the cover page for each of the Reporting Persons and is incorporated herein by reference. Such information is as of the close of business on September 30, 2025. The information required by Item 4(c)(iii) is set forth in Row 7 of the cover page for each of the Reporting Persons and is incorporated herein by reference. Such information is as of the close of business on September 30, 2025. The information required by Item 4(c)(iv) is set forth in Row 8 of the cover page for each of the Reporting Persons and is incorporated herein by reference. Such information is as of the close of business on September 30, 2025. N Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Point72 Asset Management, L.P. /s/ Jason M. Colombo 11/14/2025 Point72 Capital Advisors, Inc. /s/ Jason M. Colombo 11/14/2025 Point72 Biotech Private Investments, LLC /s/ Vincent Tortorella 11/14/2025 Differentiated Ventures Investments, LLC /s/ Vincent Tortorella 11/14/2025 72 Investment Holdings, LLC /s/ Jason M. Colombo 11/14/2025 Steven A. Cohen /s/ Jason M. Colombo 11/14/2025