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    <nameOfIssuer>58 COM INC</nameOfIssuer>
    <titleOfClass>SPON ADR REP A</titleOfClass>
    <cusip>31680Q104</cusip>
    <value>80482</value>
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    <nameOfIssuer>ALIBABA GROUP HLDG LTD</nameOfIssuer>
    <titleOfClass>SPONSORED ADS</titleOfClass>
    <cusip>01609W102</cusip>
    <value>193520</value>
    <shrsOrPrnAmt>
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    <nameOfIssuer>APELLIS PHARMACEUTICALS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>03753U106</cusip>
    <value>29410</value>
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      <Sole>2229708</Sole>
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      <None>0</None>
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    <nameOfIssuer>ARCUS BIOSCIENCES INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>03969F109</cusip>
    <value>4577</value>
    <shrsOrPrnAmt>
      <sshPrnamt>425000</sshPrnamt>
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    <votingAuthority>
      <Sole>425000</Sole>
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      <None>0</None>
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    <nameOfIssuer>ARVINAS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>04335A105</cusip>
    <value>8031</value>
    <shrsOrPrnAmt>
      <sshPrnamt>625000</sshPrnamt>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>625000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>BEIGENE LTD</nameOfIssuer>
    <titleOfClass>SPONSORED ADR</titleOfClass>
    <cusip>07725L102</cusip>
    <value>622467</value>
    <shrsOrPrnAmt>
      <sshPrnamt>4437953</sshPrnamt>
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      <Sole>4437953</Sole>
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      <None>0</None>
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    <nameOfIssuer>BILIBILI INC</nameOfIssuer>
    <titleOfClass>SPONS ADS REP Z</titleOfClass>
    <cusip>090040106</cusip>
    <value>31776</value>
    <shrsOrPrnAmt>
      <sshPrnamt>2177931</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>2177931</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>BLUEPRINT MEDICINES CORP</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>09627Y109</cusip>
    <value>77142</value>
    <shrsOrPrnAmt>
      <sshPrnamt>1430949</sshPrnamt>
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    <votingAuthority>
      <Sole>1430949</Sole>
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      <None>0</None>
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    <nameOfIssuer>BRIGHT SCHOLAR ED HLDGS LTD</nameOfIssuer>
    <titleOfClass>SPONSORED ADS</titleOfClass>
    <cusip>109199109</cusip>
    <value>36709</value>
    <shrsOrPrnAmt>
      <sshPrnamt>3985797</sshPrnamt>
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      <Sole>3985797</Sole>
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      <None>0</None>
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    <nameOfIssuer>CHINA BIOLOGIC PRODS HLDGS I</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>G21515104</cusip>
    <value>208844</value>
    <shrsOrPrnAmt>
      <sshPrnamt>2751200</sshPrnamt>
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    <votingAuthority>
      <Sole>2751200</Sole>
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      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>EIDOS THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>28249H104</cusip>
    <value>2458</value>
    <shrsOrPrnAmt>
      <sshPrnamt>178600</sshPrnamt>
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    <votingAuthority>
      <Sole>178600</Sole>
      <Shared>0</Shared>
      <None>0</None>
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    <nameOfIssuer>FANG HLDGS LTD</nameOfIssuer>
    <titleOfClass>ADR</titleOfClass>
    <cusip>30711Y102</cusip>
    <value>2145</value>
    <shrsOrPrnAmt>
      <sshPrnamt>1500000</sshPrnamt>
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    <votingAuthority>
      <Sole>1500000</Sole>
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      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>FIBROGEN INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>31572Q808</cusip>
    <value>92712</value>
    <shrsOrPrnAmt>
      <sshPrnamt>2003287</sshPrnamt>
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      <Sole>2003287</Sole>
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      <None>0</None>
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    <nameOfIssuer>G1 THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>3621LQ109</cusip>
    <value>18182</value>
    <shrsOrPrnAmt>
      <sshPrnamt>949431</sshPrnamt>
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      <Sole>949431</Sole>
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      <None>0</None>
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    <nameOfIssuer>IKANG HEALTHCARE GROUP INC</nameOfIssuer>
    <titleOfClass>SPONSORED ADR</titleOfClass>
    <cusip>45174L108</cusip>
    <value>59567</value>
    <shrsOrPrnAmt>
      <sshPrnamt>2922834</sshPrnamt>
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      <Sole>2922834</Sole>
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      <None>0</None>
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    <nameOfIssuer>IQIYI INC</nameOfIssuer>
    <titleOfClass>SPONSORED ADS</titleOfClass>
    <cusip>46267X108</cusip>
    <value>16845</value>
    <shrsOrPrnAmt>
      <sshPrnamt>1132816</sshPrnamt>
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      <Sole>1132816</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>JD COM INC</nameOfIssuer>
    <titleOfClass>SPON ADR CL A</titleOfClass>
    <cusip>47215P106</cusip>
    <value>314813</value>
    <shrsOrPrnAmt>
      <sshPrnamt>15041243</sshPrnamt>
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      <Sole>15041243</Sole>
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      <None>0</None>
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    <nameOfIssuer>KINIKSA PHARMACEUTICALS LTD</nameOfIssuer>
    <titleOfClass>COM CL A</titleOfClass>
    <cusip>G5269C101</cusip>
    <value>39014</value>
    <shrsOrPrnAmt>
      <sshPrnamt>1388888</sshPrnamt>
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      <Sole>1388888</Sole>
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      <None>0</None>
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    <nameOfIssuer>LINE CORP</nameOfIssuer>
    <titleOfClass>SPONSORED ADR</titleOfClass>
    <cusip>53567X101</cusip>
    <value>41197</value>
    <shrsOrPrnAmt>
      <sshPrnamt>1207763</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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      <Sole>1207763</Sole>
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      <None>0</None>
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    <nameOfIssuer>LOXO ONCOLOGY INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>548862101</cusip>
    <value>18391</value>
    <shrsOrPrnAmt>
      <sshPrnamt>131300</sshPrnamt>
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    <votingAuthority>
      <Sole>131300</Sole>
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      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>MELCO RESORT ENTERTAINMENT L</nameOfIssuer>
    <titleOfClass>ADR</titleOfClass>
    <cusip>585464100</cusip>
    <value>455</value>
    <shrsOrPrnAmt>
      <sshPrnamt>25814</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <votingAuthority>
      <Sole>25814</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>MONDELEZ INTL INC</nameOfIssuer>
    <titleOfClass>CL A</titleOfClass>
    <cusip>609207105</cusip>
    <value>141276</value>
    <shrsOrPrnAmt>
      <sshPrnamt>3529264</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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      <Sole>3529264</Sole>
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      <None>0</None>
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    <nameOfIssuer>MYOKARDIA INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>62857M105</cusip>
    <value>41938</value>
    <shrsOrPrnAmt>
      <sshPrnamt>858340</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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      <Sole>858340</Sole>
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      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>NEON THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>64050Y100</cusip>
    <value>1572</value>
    <shrsOrPrnAmt>
      <sshPrnamt>312500</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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      <Sole>312500</Sole>
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      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>PINDUODUO INC</nameOfIssuer>
    <titleOfClass>SPONSORED ADS</titleOfClass>
    <cusip>722304102</cusip>
    <value>38823</value>
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      <sshPrnamt>1730096</sshPrnamt>
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      <Sole>1730096</Sole>
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      <None>0</None>
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    <nameOfIssuer>PROTEOSTASIS THERAPEUTICS IN</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>74373B109</cusip>
    <value>2806</value>
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      <sshPrnamt>865923</sshPrnamt>
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      <Sole>865923</Sole>
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    <nameOfIssuer>PUXIN LTD</nameOfIssuer>
    <titleOfClass>ADS</titleOfClass>
    <cusip>74704P108</cusip>
    <value>2896</value>
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      <sshPrnamtType>SH</sshPrnamtType>
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      <Sole>490050</Sole>
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      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>SNAP INC</nameOfIssuer>
    <titleOfClass>CL A</titleOfClass>
    <cusip>83304A106</cusip>
    <value>38157</value>
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    <nameOfIssuer>SOHU COM LTD</nameOfIssuer>
    <titleOfClass>SPONSORED ADS</titleOfClass>
    <cusip>83410S108</cusip>
    <value>13971</value>
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    </votingAuthority>
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    <nameOfIssuer>TAL ED GROUP</nameOfIssuer>
    <titleOfClass>SPONSORED ADS</titleOfClass>
    <cusip>874080104</cusip>
    <value>199452</value>
    <shrsOrPrnAmt>
      <sshPrnamt>7475723</sshPrnamt>
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      <Sole>7475723</Sole>
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      <None>0</None>
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    <nameOfIssuer>TENCENT MUSIC ENTMT GROUP</nameOfIssuer>
    <titleOfClass>SPON ADS</titleOfClass>
    <cusip>88034P109</cusip>
    <value>19440</value>
    <shrsOrPrnAmt>
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    <nameOfIssuer>YY INC</nameOfIssuer>
    <titleOfClass>ADS REPCOM CLA</titleOfClass>
    <cusip>98426T106</cusip>
    <value>11582</value>
    <shrsOrPrnAmt>
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      <Sole>193490</Sole>
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      <None>0</None>
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