<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <!-- Generated by Workiva -->
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001973524</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001761918</issuerCik>
      <issuerName>Erasca, Inc.</issuerName>
      <secFileNumber>001-40602</secFileNumber>
      <issuerAddress>
        <com:street1>3115 MERRYFIELD ROW</com:street1>
        <com:street2>STE 300</com:street2>
        <com:city>San Diego</com:city>
        <com:stateOrCountry>CA</com:stateOrCountry>
        <com:zipCode>92121</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>858-465-6511</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Erasca Foundation</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Erasca Foundation</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Merrill Lynch</name>
        <address>
          <com:street1>6002 El Tordo</com:street1>
          <com:street2>PO Box 7297</com:street2>
          <com:city>Rancho Santa Fe</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92067</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>8333</noOfUnitsSold>
      <aggregateMarketValue>12942.2</aggregateMarketValue>
      <noOfUnitsOutstanding>283670139</noOfUnitsOutstanding>
      <approxSaleDate>09/15/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>07/20/2021</acquiredDate>
      <natureOfAcquisitionTransaction>Donation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Erasca, Inc</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>10193557</amountOfSecuritiesAcquired>
      <paymentDate>07/20/2021</paymentDate>
      <natureOfPayment>Donation</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Erasca Foundation</name>
        <address>
          <com:street1>3115 MERRYFIELD ROW</com:street1>
          <com:street2>STE 300</com:street2>
          <com:city>San Diego</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92121</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>08/15/2025</saleDate>
      <amountOfSecuritiesSold>8333</amountOfSecuritiesSold>
      <grossProceeds>12834.87</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Erasca Foundation</name>
        <address>
          <com:street1>3115 MERRYFIELD ROW</com:street1>
          <com:street2>STE 300</com:street2>
          <com:city>San Diego</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92121</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>07/15/2025</saleDate>
      <amountOfSecuritiesSold>8333</amountOfSecuritiesSold>
      <grossProceeds>12094.6</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Erasca Foundation</name>
        <address>
          <com:street1>3115 MERRYFIELD ROW</com:street1>
          <com:street2>STE 300</com:street2>
          <com:city>San Diego</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92121</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>06/16/2025</saleDate>
      <amountOfSecuritiesSold>8333</amountOfSecuritiesSold>
      <grossProceeds>12090.87</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>09/15/2025</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>01/10/2024</planAdoptionDate>
      </planAdoptionDates>
      <signature>David Chacko</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
