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Stock-based Compensation - Assumptions used to Determine Fair Value of Stock Option Grants and Stock to be Purchased under ESPP (Details)
3 Months Ended 6 Months Ended
Jun. 30, 2022
Jun. 30, 2021
Jun. 30, 2022
Jun. 30, 2021
Stock Options        
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]        
Risk-free interest rate, minimum 2.53% 1.02% 1.46% 0.59%
Risk-free interest rate, maximum 3.23% 1.09% 3.23% 1.09%
Expected volatility, minimum 85.51% 82.08% 85.51% 82.08%
Expected volatility, maximum 87.11% 82.54% 87.11% 83.88%
Expected term (in years)   6 years 29 days   6 years 29 days
Expected dividend yield 0.00% 0.00% 0.00% 0.00%
ESPP        
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]        
Risk-free interest rate, minimum 2.24%   2.24%  
Risk-free interest rate, maximum 3.14%   3.14%  
Expected volatility, minimum 84.74%   84.74%  
Expected volatility, maximum 87.89%   87.89%  
Expected dividend yield 0.00%   0.00%  
Minimum | Stock Options        
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]        
Expected term (in years) 5 years 6 months   5 years 6 months  
Minimum | ESPP        
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]        
Expected term (in years) 6 months   6 months  
Maximum | Stock Options        
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]        
Expected term (in years) 6 years 29 days   6 years 29 days  
Maximum | ESPP        
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]        
Expected term (in years) 1 year 11 months 26 days   1 year 11 months 26 days