X0306 4/A 2021-01-08 2021-01-11 0 0001403752 Zymeworks Inc. ZYME 0001761857 Klompas Neil A C/O ZYMEWORKS INC. 1385 WEST 8TH AVENUE, SUITE 540 VANCOUVER A1 V6H 3V9 BRITISH COLUMBIA, CANADA 0 1 0 0 Chief Financial Officer Common Shares 2021-01-08 4 A 0 284 30.92 A 9396 D Shares purchased pursuant to the Issuer's Amended and Restated Employee Stock Purchase Plan (ESPP) for the ESPP purchase period July 1, 2020 through December 31, 2020. In accordance with the ESPP, these shares were purchased at a price equal to 85% the closing price of the Issuer's common shares on July 1, 2020. The Form 4 originally filed is being amended to correct the inadvertent overstatement of the "Amount of Securities Beneficially Owned Following Reported Transactions" by ten (10) shares in Table I, column 5. /s/ Daniel Dex, Attorney-in-Fact 2021-01-11