UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
Notice of Effectiveness
Effectiveness Date:	March 22, 2019 11:15 A.M.

Form:

N-1A

CIK: 0001761673 Company Name: American Funds Multi-Sector Income Fund File Number: 333-228995 REFERENCED SERIES/CLASSES (CONTRACTS) Series ID Class/Contract Name S000065032 American Funds Multi-Sector Income Fund C000210538 Class T C000210539 Class 529-A C000210540 Class R-5E C000210541 Class R-5 C000210542 Class R-4 C000210543 Class R-3 C000210544 Class R-2E C000210545 Class R-2 C000210546 Class R-1 C000210547 Class F-3 C000210548 Class F-2 C000210549 Class F-1 C000210550 Class C C000210551 Class A C000210552 Class 529-T C000210553 Class 529-F-1 C000210554 Class 529-E C000210555 Class 529-C C000210556 Class R-6