144 0001983944 XXXXXXXX LIVE 0001761612 BICYCLE THERAPEUTICS plc 001-38916 BLOCKS A & B, PORTWAY BUILDING GRANTA PARK, GREAT ABINGTON CAMBRIDGE X0 CB21 6GS 011441223261503 Thompson Travis Alvin Officer Common Stifel Nicolaus & Co Inc

501 N Broadway St Louis MO 63102

152 3618.00 37880303 04/03/2024 NASDAQ Common 04/03/2024 Restricted Stock Units Issuer N 593 04/03/2024 Compensation Y 04/03/2024 /s/ Dominick Iadicicco, as a duly authorized representative of STIFEL, as attorney-in-fact for Travis Thompson