X0508 4 2023-07-17 0 0001761612 BICYCLE THERAPEUTICS plc BCYC 0001918147 Young Alethia C/O BICYCLE THERAPEUTICS PLC BLOCKS A & B, PORTWAY BUILDING CAMBRIDGE X0 CB21 6GS UNITED KINGDOM 0 1 0 0 Chief Financial Officer 0 Employee Share Option (Right to Buy) 26.21 2023-07-17 4 A 0 120000 0.00 A 2033-07-17 Ordinary Shares 120000 120000 D This option shall vest with respect to one-fourth (1/4) of the total number of shares underlying the option on July 17, 2024 and the remaining shares shall vest in 36 equal monthly installments thereafter, subject to the Reporting Person's continuous service through each such vesting date. /s/ Dayne Brown, Attorney-in-Fact 2023-07-19