X0306 4 2019-09-18 0 0001429560 TREVENA INC TRVN 0001761214 Yoder Robert T C/O TREVENA, INC. 955 CHESTERBROOK BOULEVARD, SUITE 110 CHESTERBROOK PA 19087 0 1 0 0 Sr. VP, Chief Business Officer Stock Option (Right to Buy) 1.00 2019-09-18 4 A 0 100000 0.00 A 2029-09-18 Common Stock 100000 100000 D The option shall vest and become exercisable with respect to one-sixteenth of the total number of shares subject to the option on a quarterly basis (every three months) from the Transaction Date listed above, subject to the reporting person's Continuous Service (as defined in the Trevena, Inc. 2013 Equity Incentive Plan, as amended) as of each such vesting date. /s/ Joel Solomon, Attorney-in-Fact 2019-09-20