X0206 3 2018-11-19 0 0001717452 Odonate Therapeutics, Inc. ODT 0001759910 Hearne Michael S C/O ODONATE THERAPEUTICS, INC. 4747 EXECUTIVE DRIVE, SUITE 510 SAN DIEGO CA 92121 0 1 0 0 Chief Financial Officer Common Stock 591 D Common Stock 12742338 I By LP Employee Stock Option (Right to Buy) 21.65 2028-04-13 Common Stock 58 D Employee Stock Option (Right to Buy) 21.08 2028-04-30 Common Stock 60 D Employee Stock Option (Right to Buy) 23.17 2028-05-15 Common Stock 55 D Employee Stock Option (Right to Buy) 23.99 2028-05-31 Common Stock 53 D Employee Stock Option (Right to Buy) 26.52 2028-06-15 Common Stock 23 D Employee Stock Option (Right to Buy) 22.08 2028-06-29 Common Stock 29 D Employee Stock Option (Right to Buy) 23.95 2028-07-13 Common Stock 27 D Employee Stock Option (Right to Buy) 19.77 2028-07-31 Common Stock 32 D Employee Stock Option (Right to Buy) 18.74 2028-08-15 Common Stock 34 D Employee Stock Option (Right to Buy) 19.19 2028-08-31 Common Stock 33 D Employee Stock Option (Right to Buy) 19.13 2028-09-14 Common Stock 33 D Employee Stock Option (Right to Buy) 19.41 2028-09-28 Common Stock 32 D Employee Stock Option (Right to Buy) 16.09 2028-10-15 Common Stock 40 D Employee Stock Option (Right to Buy) 14.50 2028-10-31 Common Stock 44 D Employee Stock Option (Right to Buy) 16.52 2028-11-15 Common Stock 38 D The securities are beneficially owned by Tang Capital Partners, LP ("TCP"). Tang Capital Management, LLC ("TCM") is the general partner of TCP. The shares reported as beneficially owned by TCP include a total of 154,285 shares of common stock that are held of record by Odonate Holdings, LLC ("Holdings"). Holdings has granted a proxy to TCP giving TCP the sole authority to vote such shares. Michael S. Hearne is the Chief Financial Officer of Odonate Therapeutics, Inc., as well as Chief Financial Officer of TCM. Mr. Hearne has a pecuniary interest in a portion of the shares beneficially held by TCP. The stock options vest with respect to 25% of the underlying shares on 4/13/2019, with the remaining shares vesting in equal monthly installments over the following three years, subject to the Reporting Person's continued service to the Issuer through each vesting date. The stock options vest with respect to 25% of the underlying shares on 4/30/2019, with the remaining shares vesting in equal monthly installments over the following three years, subject to the Reporting Person's continued service to the Issuer through each vesting date. The stock options vest with respect to 25% of the underlying shares on 5/15/2019, with the remaining shares vesting in equal monthly installments over the following three years, subject to the Reporting Person's continued service to the Issuer through each vesting date. The stock options vest with respect to 25% of the underlying shares on 5/31/2019, with the remaining shares vesting in equal monthly installments over the following three years, subject to the Reporting Person's continued service to the Issuer through each vesting date. The stock options vest with respect to 25% of the underlying shares on 6/15/2019, with the remaining shares vesting in equal monthly installments over the following three years, subject to the Reporting Person's continued service to the Issuer through each vesting date. The stock options vest with respect to 25% of the underlying shares on 6/29/2019, with the remaining shares vesting in equal monthly installments over the following three years, subject to the Reporting Person's continued service to the Issuer through each vesting date. The stock options vest with respect to 25% of the underlying shares on 7/13/2019, with the remaining shares vesting in equal monthly installments over the following three years, subject to the Reporting Person's continued service to the Issuer through each vesting date. The stock options vest with respect to 25% of the underlying shares on 7/31/2019, with the remaining shares vesting in equal monthly installments over the following three years, subject to the Reporting Person's continued service to the Issuer through each vesting date. The stock options vest with respect to 25% of the underlying shares on 8/15/2019, with the remaining shares vesting in equal monthly installments over the following three years, subject to the Reporting Person's continued service to the Issuer through each vesting date. The stock options vest with respect to 25% of the underlying shares on 8/31/2019, with the remaining shares vesting in equal monthly installments over the following three years, subject to the Reporting Person's continued service to the Issuer through each vesting date. The stock options vest with respect to 25% of the underlying shares on 9/14/2019, with the remaining shares vesting in equal monthly installments over the following three years, subject to the Reporting Person's continued service to the Issuer through each vesting date. The stock options vest with respect to 25% of the underlying shares on 9/28/2019, with the remaining shares vesting in equal monthly installments over the following three years, subject to the Reporting Person's continued service to the Issuer through each vesting date. The stock options vest with respect to 25% of the underlying shares on 10/15/2019, with the remaining shares vesting in equal monthly installments over the following three years, subject to the Reporting Person's continued service to the Issuer through each vesting date. The stock options vest with respect to 25% of the underlying shares on 10/31/2019, with the remaining shares vesting in equal monthly installments over the following three years, subject to the Reporting Person's continued service to the Issuer through each vesting date. The stock options vest with respect to 25% of the underlying shares on 11/15/2019, with the remaining shares vesting in equal monthly installments over the following three years, subject to the Reporting Person's continued service to the Issuer through each vesting date. /s/ John G. Lemkey, as attorney-in-fact for Michael S. Hearne 2018-11-29