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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2021
Mar. 31, 2020
Operating activities    
Net loss $ (50,532) $ (21,310)
Reconciliation of net loss to net cash used in operating activities:    
Stock-based compensation 5,285 2,573
Depreciation and amortization 90 73
Amortization of operating lease right-of-use assets 95 83
Non-cash interest expense related to the revenue interest liability 3,381 0
Net amortization (accretion) on investments 6 (52)
Change in fair value of derivative liability (334) 0
Change in operating assets and liabilities:    
Prepaid and other current assets (112) (158)
Other assets (160) 0
Accounts payable, accrued expenses and other liabilities 17,228 476
Operating lease liabilities (157) (36)
Net cash used in operating activities (25,210) (18,351)
Investing activities    
Proceeds from maturities of investments 48,600 29,500
Proceeds from paydown of investments 2,000 4,359
Purchase of investments (83,381) 0
Purchase of property and equipment (3) (98)
Net cash (used in) provided by investing activities (32,784) 33,761
Financing activities    
Proceeds from issuance of common stock in public offerings, net of issuance costs 6,914 44,659
Proceeds from issuance of common stock pursuant to equity award plans 80 0
Payment of issuance costs related to the revenue interest liability (400) 0
Net cash provided by financing activities 6,594 44,659
Effect of exchange rate on cash and cash equivalents (9) (4)
Net (decrease) increase in cash and cash equivalents (51,409) 60,065
Cash and cash equivalents at beginning of period 142,086 11,970
Cash and cash equivalents at end of period 90,677 72,035
Supplemental disclosure of cash flow information:    
Operating cash flows paid for operating lease $ 212 $ 107