Income Taxes - Significant Components of Deferred Taxes (Details) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Deferred tax assets:
Net operating losses	$ 31,819	$ 26,122
Tax credit carryforwards	18,501	11,294
Accrued expenses	4,027	812
Intangibles	10,277	5,560
Lease liability	543	661
Stock-based compensation	5,815	2,769
Total deferred tax assets	70,982	47,218
Deferred tax liabilities:
Operating lease right-of-use assets	(319)	(385)
Fixed assets	(138)	(184)
Total deferred tax liabilities	(457)	(569)
Valuation allowance	(70,525)	(46,649)
Net deferred tax assets	$ 0	$ 0