Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands	Total	Equity Award Plan [Member]	Revenue Interest Purchase Agreement	Underwritten Public Offerings	At-the-market Offering	Common Stock	Common Stock Equity Award Plan [Member]	Common Stock Revenue Interest Purchase Agreement	Common Stock Underwritten Public Offerings	Common Stock At-the-market Offering	Additional Paid-In Capital	Additional Paid-In Capital Equity Award Plan [Member]	Additional Paid-In Capital Revenue Interest Purchase Agreement	Additional Paid-In Capital Underwritten Public Offerings	Additional Paid-In Capital At-the-market Offering	Accumulated Deficit	Accumulated Other Comprehensive Income (Loss)
Balance at Dec. 31, 2019	$ 130,349					$ 2					$ 200,119					$ (69,901)	$ 129
Balance, Shares at Dec. 31, 2019						22,600,338
Issuance of common stock			$ 10,766	$ 114,679	$ 6,279				$ 1	$ 0			$ 10,766	$ 114,678	$ 6,279
Issuance of common stock, Shares								509,164	6,150,000	305,969
Issuance of common stock in connection with common stock option exercises	328										328
Issuance of common stock in connection with common stock option exercises, Shares						47,604
Issuance of common stock in connection with Employee Stock Purchase Plan	456										456
Issuance of common stock in connection with Employee Stock Purchase Plan, Shares						29,876
Restricted common stock vested in the period, Shares						133,593
Stock-based compensation	12,554										12,554
Net loss	(103,270)															(103,270)
Other comprehensive income (loss)	(46)																(46)
Balance at Dec. 31, 2020	172,095					$ 3					345,180					(173,171)	83
Balance, Shares at Dec. 31, 2020						29,776,544
Issuance of common stock	7,038	$ 844									7,038	$ 844
Issuance of common stock, Shares						375,654	207,595
Issuance of common stock in connection with Employee Stock Purchase Plan	1,254										1,254
Issuance of common stock in connection with Employee Stock Purchase Plan, Shares						89,211
Restricted common stock vested in the period, Shares						133,592
Stock-based compensation	23,087										23,087
Net loss	(83,988)															(83,988)
Other comprehensive income (loss)	118																(118)
Balance at Dec. 31, 2021	$ 120,212					$ 3					$ 377,403					$ (257,159)	$ (35)
Balance, Shares at Dec. 31, 2021						30,582,596