X0306 4 2022-03-09 0001661181 Organogenesis Holdings Inc. ORGO 0001759261 Montecalvo Antonio S. C/O ORGANOGENESIS HOLDINGS INC. 85 DAN ROAD CANTON MA 02021 0 1 0 0 Vice President, Health Policy Class A Common Stock 2022-03-09 4 S 0 10000 8.52 D 73221 D Class A Common Stock 2022-03-10 4 M 0 46103 3.46 A 119324 D Class A Common Stock 2022-03-10 4 M 0 22401 3.46 A 141725 D Class A Common Stock 2022-03-10 4 S 0 97436 8.39 D 44289 D Stock Option (Right to Buy) 3.46 2022-03-10 4 M 0 46103 0 D 2027-05-04 Class A Common Stock 46103 55397 D Stock Option (Right to Buy) 3.46 2022-03-10 4 M 0 22401 0 D 2027-05-04 Class A Common Stock 22401 78175 D The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $8.50 to $8.54, inclusive. The reporting person undertakes to provide to Organogenesis, any security holder of Organogenesis, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (1) to this Form 4. The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $8.34 to $8.42, inclusive. The reporting person undertakes to provide to Organogenesis, any security holder of Organogenesis, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2) to this Form 4. The shares underlying the option vested or shall vest 20% annually beginning on January 1, 2018. The shares underlying the option vested or shall vest 20% annually beginning on December 31, 2017. /s/ William R. Kolb, Attorney-in-Fact 2022-03-11