X0202 SCHEDULE 13G/A 0001137774 XXXXXXXX LIVE 4 Common Stock 5/31/2026 0001759138 Cabaletta Bio, Inc. 12674W109 2929 ARCH STREET SUITE 600 PHILADELPHIA PA 19104 Rule 13d-1(b) PRUDENTIAL FINANCIAL INC NJ 0.00 19465084.00 0.00 24267980.00 24267980.00 11.4 HC Cabaletta Bio, Inc. 2929 ARCH STREET, SUITE 600, PHILADELPHIA, PENNSYLVANIA, 19104. Prudential Financial, Inc. 751 Broad Street Newark, New Jersey 07102-3777 New Jersey N HC 24,267,980 11.4 0 19,465,084 0 24,267,980 Y N Our clients may have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such securities which are the subject of this filing. N Subsidiary Number of Shares Percentage Jennison Associates LLC IA 24,267,980 11.4 Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11. PRUDENTIAL FINANCIAL INC /s/ Richard Baker 06/05/2026