X0306 4 2021-06-16 0 0001098972 AGENUS INC AGEN 0001758521 Jeynes-Ellis Allison M C/O AGENUS INC. 3 FORBES ROAD LEXINGTON MA 02421 1 0 0 0 Common Stock 2021-06-16 4 M 0 16853 A 66176 D On June 16, 2020, Ms. Jeynes-Ellis was granted 16,853 Restricted Stock Units as part of her annual compensation for service on the Executive Committee of the Agenus Inc. Board of Directors. On June 16, 2021, this award vested in full and Ms. Jeynes-Ellis was issued the underlying 16,853 shares of common stock, all in accordance with the Agenus Inc. 2019 Equity Incentive Plan. /s/Adam Krauss, as Attorney-in-Fact for Allison Jeynes-Ellis 2021-06-21