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Income Taxes - Effective Income Tax Rate (Details)
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Income Tax Disclosure [Abstract]      
U.S. federal provision at statutory rate 21.00% 21.00% 21.00%
State income taxes 4.40% 0.70% 2.90%
Tax credits 1.50% 0.60% 1.90%
Fair value of financial instruments (2.30%) (15.60%) (6.80%)
Stock-based compensation expense 2.00% (0.40%) (0.60%)
Executive compensation (1.10%) 0.00% 0.00%
Other permanent items (0.30%) 0.00% 0.00%
Uncertain tax benefits (0.80%) (0.30%) (0.90%)
Change in valuation allowance (24.00%) (6.00%) (17.50%)
Effective tax rate 0.40% 0.00% (0.00%)