Exhibit 24.1

STERIS PLC

POWER OF ATTORNEY

FORM 10-K

Each of the undersigned hereby makes, constitutes, and appoints Daniel A. Carestio, Michael J. Tokich, Karen L. Burton, J. Adam Zangerle, and Ronald E. Snyder, and each of them, his or her true and lawful attorney, with full power of substitution, for and in his or her name, place, and stead, to affix, as attorney-in-fact, his or her signature in any and all capacities, to the Annual Report on Form 10-K of STERIS plc for its fiscal year ended March 31, 2022, and any and all amendments thereto to be filed with the Securities and Exchange Commission, Washington, D.C., under the provisions of the Securities Exchange Act of 1934, as amended, with power to file said Form 10-K and such amendments, and any and all other documents that may be required in connection therewith, with the Securities and Exchange Commission, hereby granting unto said attorneys-in-fact, and each of them, full power and authority to do and perform any and all acts and things requisite or appropriate in connection therewith, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact or any of them may lawfully do or cause to be done by virtue hereof.

IN WITNESS WHEREOF, the undersigned have executed this Power of Attorney as of the 5th day of May 2022.

/s/    RICHARD C. BREEDEN	/s/    CYNTHIA L. FELDMANN
Richard C. Breeden, Director	Cynthia L. Feldmann, Director
/s/    CHRISTOPHER S. HOLLAND	/s/    JACQUELINE B. KOSECOFF
Christopher S. Holland, Director	Jacqueline B. Kosecoff, Director
/s/  PAUL E. MARTIN	/s/   NIRAV R. SHAH
Paul E. Martin, Director	Nirav R. Shah, Director
/s/  MOHSEN M. SOHI	/s/    RICHARD M. STEEVES
Mohsen M. Sohi, Chairman of the Board	Richard M. Steeves, Director
/s/ DANIEL A. CARESTIO	/s/    KAREN L. BURTON
Daniel A. Carestio	Karen L. Burton
President and Chief Executive Officer	Vice President, Controller and Chief Accounting Officer
(Principal Executive Officer), Director	( Principal Accounting Officer)
/s/    MICHAEL J. TOKICH
Michael J. Tokich
Senior Vice President and Chief Financial Officer
(Principal Financial Officer)