X0306 4 2022-05-31 0 0001757898 STERIS plc STE 0001819129 Madsen Julia C/O 70 SIR JOHN ROGERSON'S QUAY DUBLIN L2 2 IRELAND 0 1 0 0 Senior VP, Life Sciences Ordinary Shares 2022-05-31 4 F 0 72 228.20 D 6240 D 72 shares were withheld from the 213 restricted shares that vested on May 31, 2022. These 72 shares represent the value of the taxes required to be withheld pursuant to applicable employment or tax laws, as determined by the Issuer. These 213 ordinary shares were awarded to Ms. Madsen on May 31, 2018 and May 31, 2019. These vested shares were valued at the NYSE closing market price on May 31, 2022. 3,524 of these ordinary shares are restricted. The restrictions on these ordinary shares lapse as follows: 123 on June 1, 2022; 360 on June 2, 2022; 349 on October 3, 2022; 144 on October 3, 2022; 92 on May 31, 2023; 123 on June 1, 2023; 360 on June 2, 2023; 349 on October 2, 2023; 144 on October 2, 2023; 23 on June 3, 2024; 360 on June 3, 2024; 349 on October 1, 2024; 144 on October 1, 2024; 360 on June 2, 2025 and 144 on October 1, 2025. /s/ Ronald E. Snyder, Authorized Representative under Power of Attorney 2022-06-02