X0306 4 2021-06-04 0001661181 Organogenesis Holdings Inc. ORGO 0001760663 Albert Erani Family Trust dated 12/29/2012 C/O A&E STORES, INC. 1000 HUYLER STREET TETERBORO NJ 07608 0 0 1 0 0001757286 Ades Alan A. C/O A&E STORES, INC. 1000 HUYLER STREET TETERBORO NJ 07608 1 0 1 0 0001760685 Erani Dennis C/O A&E STORES, INC. 1000 HUYLER STREET TETERBORO NJ 07608 0 0 1 0 0001757580 Organo PFG LLC C/O A&E STORES, INC. 1000 HUYLER STREET TETERBORO NJ 07608 0 0 1 0 0001757573 Organo Investors LLC C/O A&E STORES, INC. 1000 HUYLER STREET TETERBORO NJ 07608 0 0 1 0 0001757567 Alan Ades 2014 GRAT C/O A&E STORES, INC. 1000 HUYLER STREET TETERBORO NJ 07608 0 0 1 0 0001757455 Dennis Erani 2012 Issue Trust dated 12/20/12 C/O A&E STORES, INC. 1000 HUYLER STREET TETERBORO NJ 07608 0 0 1 0 0001757452 GN 2016 Organo 10-Year GRAT u/a/d September 30, 2016 35 SAWGRASS DRIVE BELLPORT NY 11713 0 0 1 0 0001757453 GN 2016 Family Trust u/a/d August 12, 2016 35 SAWGRASS DRIVE BELLPORT NY 11713 0 0 1 0 0001244191 NUSSDORF GLENN H 35 SAWGRASS DRIVE BELLPORT NY 11713 1 0 1 0 Class A Common Stock 2021-06-04 4 S 0 60000 16.22 D 59776745 D Class A Common Stock 2021-06-07 4 S 0 94612 16.14 D 59682133 D Class A Common Stock 2021-06-08 4 S 0 100000.0 15.41 D 59582133.0 D The reported securities sold were held directly by Albert Erani, who is a member of the Group (as defined below). None of the members of the Group has a pecuniary interest in the securities sold other than Albert Erani. The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $16.11 to $16.30, inclusive. The reporting person undertakes to provide to Organogenesis, any security holder of Organogenesis, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (2) to this Form 4. Reflects the total number of securities held by the Group. The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $16.00 to $16.49, inclusive. The reporting person undertakes to provide to Organogenesis, any security holder of Organogenesis, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (4) to this Form 4. The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $15.19 to $16.05, inclusive. The reporting person undertakes to provide to Organogenesis, any security holder of Organogenesis, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote (5) to this Form 4. Alan A. Ades, Albert Erani, Glenn H. Nussdorf, Dennis Erani, Starr Wisdom and certain of their respective affiliates, including Organo PFG LLC, Organo Investors LLC, Dennis Erani 2012 Issue Trust, Alan Ades as Trustee of the Alan Ades 2014 GRAT, Albert Erani Family Trust dated 12/29/2012, GN 2016 Family Trust u/a/d August 12, 2016 and GN 2016 Organo 10-Year GRAT u/a/d September 30, 2016, referred to collectively as the "Group", are parties to a Controlling Stockholders' Agreement dated December 10, 2018 with Organogenesis Holdings Inc. (the "Stockholders' Agreement"). The Stockholders' Agreement, among other things, provides for nomination rights of the Group with respect to four directors of the Issuer. As a result of the Stockholders' Agreement, the reporting persons may be deemed to be members of a group holding over 10% of the outstanding shares of common stock of the issuer for purposes of Section 13(d) of the Securities Exchange Act of 1934, as amended. This is Form 4 No. 1 of 2 filed for the Group. /s/ Stacie S. Aarestad, Attorney-in-Fact 2021-06-08