X0306 4 2020-06-10 0 0001661998 Homology Medicines, Inc. FIXX 0001757533 REICIN ALISE C/O HOMOLOGY MEDICINES, INC. ONE PATRIOTS PARK BEDFORD MA 01730 1 0 0 0 Option (Right to Buy) 16.32 2020-06-10 4 A 0 18000 0.00 A 2030-06-10 Common Stock 18000 18000 D This option shall vest and become exercisable on the earlier of June 10, 2021 or the day immediately prior to the date of the next annual meeting of the Company's stockholders occurring after the date of grant, in either case subject to the Non-Employee Director continuing in service on the Board as a Non-Employee Director through such vesting date. /s/ Bradford Smith, Attorney-in-Fact for Alise S. Reicin 2020-06-12