144 0001756991 XXXXXXXX LIVE 0000907654 ORUKA THERAPEUTICS INC 000-22873 855 Oak Grove Avenue Suite 100 Menlo Park CA 94025 6506067910 JOANA GONCALVES Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

21000 1408260.00 49542691 04/15/2026 NASDAQ Common 04/15/2026 Exercise of Stock Options Issuer N 21000 04/15/2026 Cash N 10b5-1 Sales for JOANA GONCALVES

855 Oak Grove Avenue Suite 100 Menlo Park CA 94025

Common 03/16/2026 7000 286085.80 JOANA GONCALVES

855 Oak Grove Avenue Suite 100 Menlo Park CA 94025

Common 03/16/2026 641 26473.30 10b5-1 Sales for JOANA GONCALVES

855 Oak Grove Avenue Suite 100 Menlo Park CA 94025

Common 02/17/2026 7000 226558.50 The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale. 04/15/2026 09/19/2025 /s/ Joana Goncalves