X0306 4 2022-02-25 0 0001346830 Cara Therapeutics, Inc. CARA 0001756991 Goncalves Joana C/O CARA THERAPEUTICS, INC. 4 STAMFORD PLAZA, 107 ELM STREET, 9TH FL STAMFORD CT 06902 0 1 0 0 Chief Medical Officer Common Stock 2022-02-25 4 A 0 20000 0.00 A 78507 D Common Stock 2022-02-25 4 S 0 1972 10.29 D 76535 D Employee Stock Option (Right to Buy) 10.46 2022-02-25 4 A 0 80000 0.00 A 2032-02-25 Common Stock 80000 80000 D Represents the number of shares underlying restricted stock units ("RSUs"). Each RSU represents the contingent right to receive one share of common stock of the Issuer. The RSUs vest in three equal annual installments on each of February 25, 2023, February 25, 2024 and February 25, 2025, in each case, subject to the Reporting Person's continued service (as that term is defined in the Issuer's 2014 Equity Incentive Plan) as of each such date. This sale was effected pursuant to a "sell to cover" arrangement adopted by the Reporting Person in accordance with Rule 10b5-1 on September 6, 2018 to satisfy the tax withholding obligations triggered by the vesting of RSUs reported in the Form 4 filed with the Securities and Exchange Commission on August 26, 2021, and does not represent a discretionary trade by the Reporting Person. The shares shall vest and become exercisable in a series of 48 successive equal monthly installments beginning on March 25, 2022, in each case subject to the Reporting Person's continued service as of each such date. /s/ Darren DeStefano, Attorney-in-Fact 2022-03-01