X0306 4 2021-03-22 0 0001346830 Cara Therapeutics, Inc. CARA 0001756991 Goncalves Joana C/O CARA THERAPEUTICS, INC. 4 STAMFORD PLAZA, 107 ELM STREET, 9TH FL STAMFORD CT 06902 0 1 0 0 Chief Medical Officer Common Stock 2021-03-22 4 S 0 3000 19.65 D 30610 D This sale was effected pursuant to a Rule 10b5-1 Trading Plan adopted by the Reporting Person on November 15, 2019, as amended on August 19, 2020. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $19.36 to $19.87, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote to this Form 4. /s/ Darren DeStefano, Attorney-in-Fact 2021-03-24