X0306 4 2022-03-01 0 0001142596 NUVASIVE INC NUVA 0001756949 Barry James Christopher 7475 LUSK BLVD. SAN DIEGO CA 92121 1 1 0 0 Chief Executive Officer Common Stock 2022-03-01 4 M 0 53523 0.00 A 81010 D Common Stock 2022-03-01 4 F 0 20792 54.51 D 60218 D PRSUs 0.00 2022-03-01 4 M 0 19323 0.00 D Common Stock 19323 0 D RSUs 0.00 2022-03-01 4 M 0 34200 0.00 D Common Stock 34200 0 D RSUs 0.00 2022-03-01 4 A 0 45864 0.00 A Common Stock 45864 45864 D Shares directly held by the Reporting Person. The Reporting Person also holds conditional rights to receive shares pursuant to previously disclosed Issuer equity awards. Shares withheld by the Issuer to satisfy tax withholding obligations. Each Performance Restricted Stock Unit ("PRSU") represents the right to receive one share of the Issuer's common stock upon vesting. This PRSU award was granted to the Reporting Person on November 5, 2018. In accordance with the terms of the PRSU award, the award vested as to 29,904 shares on November 5, 2021. Each Restricted Stock Unit ("RSU") represents the right to receive one share of the Issuer's common stock upon vesting. This RSU award was granted to the Reporting Person on March 1, 2019. In accordance with the terms of the PRSU award, the award vested as to 34,200 shares on March 1, 2022. This RSU award was granted to the Reporting Person on March 1, 2022. In accordance with the terms of the RSU award, the award will vest in full on March 1, 2025. /s/ Nathaniel B. Sisitsky, Attorney-in-fact for James Christopher Barry 2022-03-03