X0306 4 2022-02-10 0 0001142596 NUVASIVE INC NUVA 0001756949 Barry James Christopher 7475 LUSK BLVD. SAN DIEGO CA 92121 1 1 0 0 Chief Executive Officer PRSUs 0.00 2022-02-10 4 A 0 19323 0.00 A Common Stock 19323 19323 D Each Performance Restricted Stock Unit ("PRSU") represents the right to receive one share of the Issuer's common stock upon vesting. This PRSU award was granted to the Reporting Person on March 1, 2019. The award was granted based on a target number of shares with a performance multiplier of 0-200% based on the Issuer's non-GAAP Operating Margin over the performance period ended December 31, 2021. On February 10, 2022, the Compensation Committee of the Issuer's Board of Directors certified the Issuer's performance for purposes of the award. Based on the Issuer's performance, the award will vest as to 19,323 shares on March 1, 2022, subject to and in accordance with the terms of the award. As the award did not constitute a derivative security, it was not required to be reported and was not reported on a Form 4 at the time of grant. /s/ Nathaniel B. Sisitsky, Attorney-in-fact for James Christopher Barry 2022-02-14