X0306 4 2019-05-21 0 0001652130 Intellia Therapeutics, Inc. NTLA 0001756929 GOODMAN JESSE C/O INTELLIA THERAPEUTICS, INC. 40 ERIE STREET; SUITE 130 CAMBRIDGE MA 02139 1 0 0 0 Stock option (right to buy) 15.78 2019-05-21 4 A 0 19000 0.00 A 2029-05-20 Common Stock 19000 19000 D This option was granted on May 21, 2019 with respect to 19,000 shares of Common Stock and vests in full on the earlier to occur of (a) the first anniversary of the grant date or (b) the date of the next annual meeting of stockholders following the date of grant. /s/ Jose Rivera, Attorney-In-Fact 2019-05-22