SCHEDULE 13G 0001442891 XXXXXXXX LIVE Ordinary Shares, nominal value Euro 0.01 per share 05/09/2025 0001756594 Inventiva S.A. F5R343107 50 RUE DE DIJON DAIX I0 21121 Rule 13d-1(c) Eventide Asset Management, LLC DE 10118517.00 0.00 10118517.00 0.00 10118517.00 N 6.7 IA Finny Kuruvilla, M.D. Ph. D. X1 0.00 10118517.00 0.00 10118517.00 10118517.00 N 6.7 HC IN Robin C. John X1 0.00 10118517.00 0.00 10118517.00 10118517.00 N 6.7 HC IN Inventiva S.A. 50 RUE DE DIJON, DAIX, France, 21121 (i) Eventide Asset Management, LLC ("Eventide") (ii) Finny Kuruvilla, M.D., Ph.D. ("Kuruvilla") (iii) Robin C. John ("John") Eventide, Kuruvilla and John: One International Place, Suite 4210 Boston, Massachusetts 02110 Eventide: Delaware Kuruvilla: United States John: United States N IA HC (i) Eventide: 10,118,517 (ii) Kuruvilla: 10,118,517 (iii) John: 10,118,517 (i) Eventide: 6.7% (ii) Kuruvilla: 6.7% (iii) John: 6.7% (1) Eventide: 10,118,517 (2) Kuruvilla: 0 (3) John: 0 (1) Eventide: 0 (2) Kuruvilla: 10,118,517 (3) John: 10,118,517 (1) Eventide: 10,118,517 (2) Kuruvilla: 0 (3) John: 0 (1) Eventide: 0 (2) Kuruvilla: 10,118,517 (3) John: 10,118,517 Y N As of May 9, 2025, Eventide Asset Management, LLC, a Delaware limited liability company located at One International Place, Suite 4210, Boston, Massachusetts 02110, is the beneficial owner of 10,118,517 shares of the Issuer's Common Stock by virtue of being the investment adviser to Eventide Healthcare Innovation Fund I LP, a private fund (the "Fund"). Eventide Asset Management, LLC is the Managing Member of Eventide Healthcare Innovation Fund I GP LLC who is the general partner of the Fund. As of May 9, 2025, the Fund held 10,118,517 shares of the Issuer's Common Stock, representing 6.7% of the Issuer's outstanding Common Stock. Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. EXHIBIT 1 WHEREAS, in accordance with Rule 13d-1(k)(1) under the Securities and Exchange Act of 1934 (the "Act"), only one joint Statement and any amendments thereto need to be filed whenever one or more persons are required to file such a Statement or any amendments thereto pursuant to Section 13(d) of the Act with respect to the same securities, provided that said persons agree in writing that such Statement or amendments thereto is filed on behalf of each of them; NOW, THEREFORE, the parties hereto agree as follows: Eventide Asset Management, LLC, Finny Kuruvilla, M.D., Ph. D. and Robin C. John do hereby agree, in accordance with Rule 13d-1(k)(1) under the Act, to file a Statement on Schedule 13G relating to their ownership of the Common Stock of the Issuer, and do hereby further agree that said Statement on Schedule 13G shall be filed on behalf of each of them. Eventide Asset Management, LLC Date: May 14, 2025 By: /s/ Peter J. Luiso Name: Peter J. Luiso Title: General Counsel Date: May 14, 2025 Finny Kuruvilla, M.D., Ph. D. By: /s/ Finny Kuruvilla, M.D., Ph. D. Name: Finny Kuruvilla, M.D., Ph. D. Date: May 14, 2025 Robin C. John By: /s/ Robin C. John Name: Robin C. John Eventide Asset Management, LLC /s/ Peter J. Luiso 05/14/2025 Finny Kuruvilla, M.D. Ph. D. /s/ Finny Kuruvilla, M.D., Ph. D. 05/14/2025 Robin C. John /s/ Robin C. John 05/14/2025