SCHEDULE 13G/A 0001104659-21-016094 0001845105 XXXXXXXX LIVE 5 Ordinary Shares, nominal value EUR0.01 per share 12/31/2025 0001756594 Inventiva, S.A. 46124U107 50 rue de Dijon Daix I0 21121 Rule 13d-1(d) Sofinnova Crossover I SLP b I0 12332804.00 0.00 8433227.00 0.00 12332804.00 N 5.6 OO Note to Items 5 and 6: Sofinnova Partners SAS, a French corporation ("SP SAS"), the management company of Sofinnova Crossover I SLP ("SC"), may be deemed to have sole voting power, and Antoine Papiernik ("Papiernik"), Cedric Moreau ("Moreau"), Kinam Hong ("Hong"), Joseph Anderson ("Anderson") and Jacques Theurillat ("Theurillat"), the members of the investment committee of SC, may be deemed to have shared power to vote these shares. Note to Items 7 and 8: SP SAS, the management company of SC, may be deemed to have sole power to dispose of these shares, and Papiernik, Moreau, Hong, Anderson and Theurillat the members of the investment committee of SC, may be deemed to have shared power to dispose of these shares. Note in relation to Items 6, 8, 9, and 11: The Reporting Person beneficially owns 8,433,227 Ordinary Shares (including ordinary shares represented by American depositary shares) and has 12,332,804 voting rights related to such shares. The aggregate amount beneficially owned and percent of class reported above are based on the Reporting Person's voting rights and the 221,065,508 voting rights outstanding as of January 31, 2026. Sofinnova Crossover II SLP b I0 6753246.00 0.00 6753246.00 0.00 6753246.00 N 3.1 OO Note to Items 5 and 6: SP SAS, the management company of Sofinnova Crossover II SLP ("SC II"), may be deemed to have sole voting power, and Papiernik, Moreau, Hong, and Anderson, the members of the investment committee of SC II, may be deemed to have shared power to vote these shares. Note to Items 7 and 8: SP SAS, the management company of SC II, may be deemed to have sole power to dispose of these shares, and Papiernik, Moreau, Hong and Anderson, the members of the investment committee of SC II, may be deemed to have shared power to dispose of these shares. Note in relation to Items 6, 8, 9, and 11: The Reporting Person beneficially owns 6,753,246 Ordinary Shares (including ordinary shares represented by American depositary shares) and has 6,753,246 voting rights related to such shares. The aggregate amount beneficially owned and percent of class reported above are based on the Reporting Person's voting rights and the 221,065,508 voting rights outstanding as of January 31, 2026. Sofinnova Partners SAS, a French corporation b I0 19086050.00 0.00 15186473.00 0.00 19086050.00 N 8.6 OO Note to Items 5 and 6: SP SAS, the management company of SC and SC II, may be deemed to have sole voting power, and the members of the respective investment committees of SC and SC II, may be deemed to have shared power to vote their respective shares. Note to Items 7 and 8: SP SAS, the management company of SC and SC II, may be deemed to have sole power to dispose of these shares, and the members of the respective investment committees of SC and SC II, may be deemed to have shared power to dispose of their respective shares. Note in relation to Items 6, 8, 9, and 11: The Reporting Person beneficially owns 15,186,473 Ordinary Shares (including ordinary shares represented by American depositary shares) and has 19,086,050 voting rights related to such shares. The aggregate amount beneficially owned and percent of class reported above are based on the Reporting Person's voting rights and the 221,065,508 voting rights outstanding as of January 31, 2026. Antoine Papiernik b I0 19086050.00 0.00 15186473.00 0.00 19086050.00 N 8.6 IN Note to Items 5 and 6: SP SAS, the management company of SC and SC II, may be deemed to have sole voting power, and Papiernik, a member of the investment committee of SC and SC II, may be deemed to have shared power to vote these shares. Note to Items 7 and 8: SP SAS, the management company of SC and SC II, may be deemed to have sole power to dispose of these shares, and Papiernik, a member of the investment committee of SC and SC II, may be deemed to have shared power to dispose of these shares. Note in relation to Items 6, 8, 9, and 11: The Reporting Person beneficially owns 15,186,473 Ordinary Shares (including ordinary shares represented by American depositary shares) and has 19,086,050 voting rights related to such shares. The aggregate amount beneficially owned and percent of class reported above are based on the Reporting Person's voting rights and the 221,065,508 voting rights outstanding as of January 31, 2026. Cedric Moreau b I0 19086050.00 0.00 15186473.00 0.00 19086050.00 N 8.6 IN Note to Items 5 and 6: SP SAS, the management company of SC and SC II, may be deemed to have sole voting power, and Moreau, a member of the investment committee of SC and SC II, may be deemed to have shared power to vote these shares. Note to Items 7 and 8: SP SAS, the management company of SC and SC II, may be deemed to have sole power to dispose of these shares, and Moreau, a member of the investment committee of SC and SC II, may be deemed to have shared power to dispose of these shares. Note in relation to Items 6, 8, 9, and 11: The Reporting Person beneficially owns 15,186,473 Ordinary Shares (including ordinary shares represented by American depositary shares) and has 19,086,050 voting rights related to such shares. The aggregate amount beneficially owned and percent of class reported above are based on the Reporting Person's voting rights and the 221,065,508 voting rights outstanding as of January 31, 2026. Kinam Hong b X1 19086050.00 0.00 15186473.00 0.00 19086050.00 N 8.6 IN Note to Items 5 and 6: SP SAS, the management company of SC and SC II, may be deemed to have sole voting power, and Hong, a member of the investment committee of SC and SC II, may be deemed to have shared power to vote these shares. Note to Items 7 and 8: SP SAS, the management company of SC and SC II, may be deemed to have sole power to dispose of these shares, and Hong, a member of the investment committee of SC and SC II, may be deemed to have shared power to dispose of these shares. Note in relation to Items 6, 8, 9, and 11: The Reporting Person beneficially owns 15,186,473 Ordinary Shares (including ordinary shares represented by American depositary shares) and has 19,086,050 voting rights related to such shares. The aggregate amount beneficially owned and percent of class reported above are based on the Reporting Person's voting rights and the 221,065,508 voting rights outstanding as of January 31, 2026. Joseph Anderson b X0 19086050.00 0.00 15186473.00 0.00 19086050.00 N 8.6 IN Note to Items 5 and 6: SP SAS, the management company of SC and SC II, may be deemed to have sole voting power, and Anderson, a member of the investment committee of SC and SC II, may be deemed to have shared power to vote these shares. Note to Items 7 and 8: SP SAS, the management company of SC and SC II, may be deemed to have sole power to dispose of these shares, and Anderson, a member of the investment committee of SC and SC II, may be deemed to have shared power to dispose of these shares. Note in relation to Items 6, 8, 9, and 11: The Reporting Person beneficially owns 15,186,473 Ordinary Shares (including ordinary shares represented by American depositary shares) and has 19,086,050 voting rights related to such shares. The aggregate amount beneficially owned and percent of class reported above are based on the Reporting Person's voting rights and the 221,065,508 voting rights outstanding as of January 31, 2026. Jacques Theurillat b V8 12332804.00 0.00 8433227.00 0.00 12332804.00 N 5.6 IN Note to Items 5 and 6: SP SAS, the management company of SC, may be deemed to have sole voting power, and Theurillat, a member of the investment committee of SC, may be deemed to have shared power to vote these shares. Note to Items 7 and 8: SP SAS, the management company of SC, may be deemed to have sole power to dispose of these shares, and Theurillat, a member of the investment committee of SC, may be deemed to have shared power to dispose of these shares. Note in relation to Items 6, 8, 9, and 11: The Reporting Person beneficially owns 8,433,227 Ordinary Shares (including ordinary shares represented by American depositary shares) and has 12,332,804 voting rights related to such shares. The aggregate amount beneficially owned and percent of class reported above are based on the Reporting Person's voting rights and the 221,065,508 voting rights outstanding as of January 31, 2026. Inventiva, S.A. 50 rue de Dijon Daix, I0, 21121 The persons and entities filing this Schedule 13G are Sofinnova Crossover I SLP ("SC"), Sofinnova Crossover II SLP ("SC II"), Sofinnova Partners SAS ("SP SAS"), and Antoine Papiernik ("Papiernik"), Cedric Moreau ("Moreau), Kinam Hong ("Hong"), and Joseph Anderson ("Anderson"), the members of the investment committee of SC II , and Jacques Theurillat ("Theurillat"), together with Papiernik, Moreau, Hong, and Anderson the members of the investment committee of SC (together with SC, SC II, and SP SAS, the "Filing Persons"). SP SAS is the management company of SC and SC II. The address of the principal place of business for each of the Filing Persons is Sofinnova Partners SAS, 7-11 boulevard Hausmann 75009 Paris, France. SC and SC II are French Partnerships. SP SAS is a French Corporation. Papiernik and Moreau are French citizens. Hong is a U.S. citizen. Anderson is a British citizen. Theurillat is a Swiss citizen. Y See Row 9 of the cover page for each of the Filing Persons. The filing of this Schedule 13G shall not be construed as an admission by Papiernik, Moreau, Hong, Anderson and Theurillat that such person is, for the purposes of Section 13(d) of the Securities Exchange Act of 1934, the beneficial owner of any securities covered by this Statement. See Row 11 of the cover page for each of the Filing Persons. Ownership is stated as of December 31, 2025 and the ownership percentages are based on 206,407,475 shares outstanding as of, January 31, 2026 as disclosed by Inventiva S.A. on its website in accordance with article 223-16 of the general regulations of the AMF (French Financial Markets Authority). Voting right percentage is based on 221,065,508 outstanding voting rights as of January 31, 2026. See Row 5 of the cover page for each of the Filing Persons, which is incorporated herein by reference. See Row 6 of the cover page for each of the Filing Persons, which is incorporated herein by reference. See Row 7 of the cover page for each of the Filing Persons, which is incorporated herein by reference. See Row 8 of the cover page for each of the Filing Persons, which is incorporated herein by reference. Y Y Y Y Y Y Exhibit 1 - Joint Filing Agreement Sofinnova Crossover I SLP /s/ Antoine Papiernik 02/17/2026 Sofinnova Crossover II SLP /s/ Antoine Papiernik 02/17/2026 Sofinnova Partners SAS, a French corporation /s/ Antoine Papiernik 02/17/2026 Antoine Papiernik /s/ Antoine Papiernik 02/17/2026 Cedric Moreau /s/ Cedric Moreau 02/17/2026 Kinam Hong /s/ Kinam Hong 02/17/2026 Joseph Anderson /s/ Joseph Anderson 02/17/2026 Jacques Theurillat /s/ Jacques Theurillat 02/17/2026