<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2025-09-16</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001433607</issuerCik>
        <issuerName>InspireMD, Inc.</issuerName>
        <issuerTradingSymbol>NSPR</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001756438</rptOwnerCik>
            <rptOwnerName>Dearen Danny L.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O INSPIREMD, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>6303 WATERFORD DISTRICT DRIVE, SUITE 215</rptOwnerStreet2>
            <rptOwnerCity>MIAMI</rptOwnerCity>
            <rptOwnerState>FL</rptOwnerState>
            <rptOwnerZipCode>33126</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>58017</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Options to purchase common stock (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>2.41</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F2"/>
            </exerciseDate>
            <expirationDate>
                <value>2035-09-16</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>28206</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">These shares of common stock represent (1) 2,000 shares of common stock purchased by the Reporting Person on the open market and (2) 56,017 shares of restricted stock, which vest on September 16, 2026, subject to the Reporting Person's continued service, provided that in the event that the Reporting Person is either (i) not reelected as a director at the Company's 2026 annual meeting of stockholders, or (ii) not nominated for reelection as a director at the Company's 2026 annual meeting of stockholders, any unvested shares of restricted stock will vest in full and become exercisable on the date of the decision not to reelect or nominate him (as applicable).</footnote>
        <footnote id="F2">The options vest and become exercisable on September 16, 2026, subject to the Reporting Person's continued service, provided that in the event that the Reporting Person is either (i) not reelected as a director at the Company's 2026 annual meeting of stockholders, or (ii) not nominated for reelection as a director at the Company's 2026 annual meeting of stockholders, any unvested options will vest in full and become exercisable on the date of the decision not to reelect or nominate him (as applicable).</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Danny L. Dearen</signatureName>
        <signatureDate>2025-09-23</signatureDate>
    </ownerSignature>
</ownershipDocument>
