Income Taxes - Schedule of Net deferred Tax Assets (Detail) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020	Dec. 28, 2019
Deferred tax assets:
Net operating loss carryforwards	$ 94,672	$ 81,390
Capitalized research and development expense	4,291	6,136
Research and development tax credit carryforwards	12,186	11,541
Accrued expenses	2,528	1,390
Stock-based compensation expense	2,254	791
Deferred rent		79
Lease liability	2,299
Other	170	132
Total deferred tax assets	118,400	101,459
Deferred tax liabilities:
Other	(674)	(218)
Right-of-use assets	(1,562)
Unrealized gain (loss)		(212)
Total deferred tax liabilities	(2,236)	(430)
Valuation allowance	$ (116,164)	$ (101,029)	$ (95,024)