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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Cash flows from operating activities:      
Net loss $ (36,231) $ (44,215) $ (28,748)
Adjustments to reconcile net loss to net cash used in operating activities:      
Depreciation and amortization expense 3,478 1,817 1,577
Stock-based compensation expense 10,321 6,878 2,414
Loss on extinguishment of debt 575    
Loss on sale of marketable securities 107    
Non-cash interest and end of term accretion expense 465 540 511
Non-cash lease expense 717 829  
Net amortization of premiums on marketable securities 381 1,356 634
Unrealized foreign currency transaction (gains) losses 1,129 928 (1,065)
Changes in operating assets and liabilities:      
Accounts receivable (21,678) 840 (218)
Inventory (8,024) (4,894) (1,740)
Prepaid expenses and other current assets 2,521 (3,151) (769)
Accounts payable (3,270) 5,090 (5,802)
Accrued expenses and other current liabilities 3,437 4,875 1,948
Deferred revenue   7 60
Operating lease liabilities 255 236  
Deferred rent     933
Net cash used in operating activities (45,817) (28,864) (30,265)
Cash flows from investing activities:      
Purchases of property and equipment (11,907) (3,519) (455)
Purchases of marketable securities (10,496) (72,024) (121,793)
Proceeds from sales and maturities of marketable securities 76,916 104,810 80,650
Net cash provided by (used) in investing activities 54,513 29,267 (41,598)
Cash flows from financing activities:      
Proceeds from issuance of long-term debt, net of issuance costs 58,509    
Repayments of long-term debt (36,050)    
Proceeds from issuance of common stock in public offering, net of underwriting discounts and commissions and issuance costs paid 139,854   74,965
Proceeds from issuance of common stock upon exercise of stock options 4,667 974 227
Proceeds from issuance of warrants 438    
Proceeds from issuance of common stock in connection with employee stock purchase plan 509 419 357
Proceeds from Paycheck Protection Program loan     2,249
Repayment of Paycheck Protection Program loan     (2,249)
Net cash provided by financing activities 167,927 1,393 75,549
Effect of exchange rate changes on cash, cash equivalents and restricted cash (1,021) (797) 803
Net increase in cash, cash equivalents and restricted cash 175,602 999 4,489
Cash, cash equivalents and restricted cash, beginning of period 26,080 25,081 20,592
Cash, cash equivalents and restricted cash, end of period 201,682 26,080 25,081
Supplemental disclosure of cash flow information:      
Cash paid for interest 3,260 3,334 3,475
Supplemental disclosure of non-cash investing and financing activities:      
Transfers of inventory to property and equipment 2,135 1,823 1,191
Purchases of property and equipment included in accounts payable and accrued expenses 62 1,200  
Reconciliation of cash, cash equivalents and restricted cash:      
Cash and cash equivalents 201,182 25,580 24,581
Restricted cash 500 500 500
Total cash, cash equivalents and restricted cash shown in the statement of cash flows $ 201,682 $ 26,080 $ 25,081