X0306 4 2023-02-14 0 0001756262 TransMedics Group, Inc. TMDX 0001430462 Khayal Tamer I C/O TRANSMEDICS GROUP, INC. 200 MINUTEMAN ROAD ANDOVER MA 01810 0 1 0 0 Chief Commercial Officer Common Stock 2023-02-14 4 M 0 4070 16.00 A 5370 D Common Stock 2023-02-14 4 S 0 4070 70.15 D 1300 D Common Stock 11051 I By the Tamer Ibrahim Ahmed Khayal Trust Common Stock 24776 I By the Khayal Family 2021 Irrevocable Trust Stock Option (Right to Buy) 16.00 2023-02-14 4 M 0 4070 0.00 D 2029-05-01 Common Stock 4070 40215 D The reported transactions were effected pursuant to a Rule 10b5-1 trading plan. The price reported is a weighted average price. These shares were sold in multiple transactions ranging from $70.00 to $70.35, inclusive. The Reporting Person undertakes to provide to the Company, any security holder of the Company or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. The option vests in equal monthly installments over four years beginning on the date of grant, May 1, 2019. By: /s/ Stephen Gordon, Attorney-in-Fact 2023-02-16