X0508 4 2023-12-19 0001116463 ORASURE TECHNOLOGIES INC OSUR 0001756089 Weber Kathleen Gallagher C/O ORASURE TECHNOLOGIES, INC. 220 EAST FIRST STREET BETHLEHEM PA 18015 0 1 0 0 Chief Product Officer 1 Common Stock 2023-12-19 4 M 0 4129 5.7149 A 278829 D Common Stock 2023-12-19 4 S 0 24129 8.0492 D 254700 D Non-Qualified Stock Options 5.7149 2023-12-19 4 M 0 4129 0 D 2024-02-03 Common Stock 4129 0 D The reported transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 25, 2023. The price reported in column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $8.00 to $8.095, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Non-qualified stock options granted on February 3, 2014, vesting 25% at the end of 12 months after the grant date and 75% ratably on a monthly basis over the next 36 months. Vesting shall cease upon voluntary termination of employment. /s/ Michele Anthony, Attorney-In-Fact 2023-12-21