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Share-based Compensation Plans (Details)
$ / shares in Units, $ in Thousands
12 Months Ended
Dec. 31, 2024
USD ($)
TradingDay
$ / shares
shares
Dec. 31, 2023
USD ($)
$ / shares
shares
Share-based Compensation Plans    
Share-based compensation | $ $ 625 $ 1,067
Research and development    
Share-based Compensation Plans    
Share-based compensation | $ 91 421
General and administrative    
Share-based Compensation Plans    
Share-based compensation | $ $ 534 $ 646
Restricted Stock Awards    
Share-based Compensation Plans    
Granted (in shares) 65,000 200,000
Vested (in shares) 71,763  
Restricted Stock Awards | Director    
Share-based Compensation Plans    
Expected period to recognize the expense 2 years 8 months 4 days  
Unrecognized share-based compensation expense | $ $ 400  
Performance stock options    
Share-based Compensation Plans    
Number of shares vested 0 0
Share based compensation expense | $ $ 0 $ 0
Employee Stock Option    
Share-based Compensation Plans    
outstanding stock options 335,448 291,368
Market conditions forfeited 11,769  
Weighted average exercise price | $ / shares $ 158.98 $ 189.09
Expected period to recognize the expense 3 years 7 months 20 days  
Weighted average grant date fair value per option share | $ / shares $ 2.8 $ 2.95
Total intrinsic value | $ $ 0 $ 0
Unrecognized share-based compensation expense | $ $ 400  
Granted (in shares) 55,849 4,000
Market-based Stock Options    
Share-based Compensation Plans    
Threshold consecutive trading days, used as a base for measurement of vesting of stock awards | TradingDay 30  
outstanding stock options 0  
Market conditions forfeited 7,500  
Granted (in shares) 0 0
Market-based Stock Options | Minimum    
Share-based Compensation Plans    
Expected option term (in years) 4 years  
Market-based Stock Options | Maximum    
Share-based Compensation Plans    
Expected option term (in years) 4 years 7 months 6 days