<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
	<headerData>
        <submissionType>144</submissionType>
                <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001755098</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
        <liveTestFlag>LIVE</liveTestFlag>




                </filerInfo>
    </headerData>

     <formData>
        <issuerInfo>
            <issuerCik>0001650664</issuerCik>
			<issuerName>EDITAS MEDICINE, INC.</issuerName>


			    <secFileNumber>001-37687</secFileNumber>


			<issuerAddress>
				<com:street1>c/o Editas Medicine, Inc.</com:street1>
                				<com:street2>11 Hurley St.</com:street2>
                				<com:city>Cambridge</com:city>
				<com:stateOrCountry>MA</com:stateOrCountry>
				<com:zipCode>02141</com:zipCode>
			</issuerAddress>

			<issuerContactPhone>617-401-9000</issuerContactPhone>
			<nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Michelle  Robertson</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>

			<relationshipsToIssuer>

				    <relationshipToIssuer>Officer</relationshipToIssuer>

			</relationshipsToIssuer>
		</issuerInfo>

				          <securitiesInformation>
			<securitiesClassTitle>Common Stock</securitiesClassTitle>
			<brokerOrMarketmakerDetails>
				<name>E*Trade Financial Corporation</name>
				<address>
				<com:street1>3 Edison Drive</com:street1>
                				<com:city>Alphareta</com:city>
				<com:stateOrCountry>GA</com:stateOrCountry>
				<com:zipCode>30005</com:zipCode>
				</address>
			</brokerOrMarketmakerDetails>
			<noOfUnitsSold>3000</noOfUnitsSold>
			<aggregateMarketValue>10845.12</aggregateMarketValue>
			<noOfUnitsOutstanding>68995606</noOfUnitsOutstanding>
			<approxSaleDate>05/11/2023</approxSaleDate>
			<securitiesExchangeName>Nasdaq</securitiesExchangeName>
		</securitiesInformation>

    		       <securitiesToBeSold>
         <securitiesClassTitle>Common Stock</securitiesClassTitle>
         <acquiredDate>05/10/2023</acquiredDate>
         <natureOfAcquisitionTransaction>Restricted Stock Unit Vesting</natureOfAcquisitionTransaction>
                  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
                  <isGiftTransaction>N</isGiftTransaction>
		          <amountOfSecuritiesAcquired>3344</amountOfSecuritiesAcquired>
                  <paymentDate>05/10/2023</paymentDate>
                  <natureOfPayment>Equity Compensation</natureOfPayment>
      </securitiesToBeSold>

    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>


     <securitiesSoldInPast3Months>
         <sellerDetails>
            <name>Michelle Robertson</name>
            <address>
               <com:street1>11 Hurley Street</com:street1>
                              <com:city>Cambridge</com:city>
               <com:stateOrCountry>MA</com:stateOrCountry>
               <com:zipCode>02141</com:zipCode>
            </address>
         </sellerDetails>
         <securitiesClassTitle>Common Stock</securitiesClassTitle>
         <saleDate>02/13/2023</saleDate>
         <amountOfSecuritiesSold>4287</amountOfSecuritiesSold>
         <grossProceeds>41435.14</grossProceeds>
      </securitiesSoldInPast3Months>

     <securitiesSoldInPast3Months>
         <sellerDetails>
            <name>Michelle Robertson</name>
            <address>
               <com:street1>11 Hurley Street</com:street1>
                              <com:city>Cambridge</com:city>
               <com:stateOrCountry>MA</com:stateOrCountry>
               <com:zipCode>02141</com:zipCode>
            </address>
         </sellerDetails>
         <securitiesClassTitle>Common Stock</securitiesClassTitle>
         <saleDate>03/03/2023</saleDate>
         <amountOfSecuritiesSold>184</amountOfSecuritiesSold>
         <grossProceeds>1635.76</grossProceeds>
      </securitiesSoldInPast3Months>


        <noticeSignature>
            <noticeDate>05/11/2023</noticeDate>
                        <planAdoptionDates>
		                                     <planAdoptionDate>12/30/2019</planAdoptionDate>

            </planAdoptionDates>
                        <signature>  /s/ Michelle Robertson</signature>
        </noticeSignature>
	</formData>
    </edgarSubmission>
