Leases - Additional Information (Details) - USD ($) $ in Thousands	1 Months Ended			12 Months Ended
	Dec. 31, 2023	Oct. 31, 2022	Sep. 30, 2021	Dec. 31, 2023	Dec. 31, 2022
Leases [Line Items]
ROU asset	$ 2,187			$ 2,187	$ 31,633
Lease liability	27,429			27,429
Remaining right-of-use asset balance	$ 2,200			2,200
Operating lease costs				9,700	6,600
Cash paid for operating lease				4,800	4,800
Variable lease costs				$ 900	$ 3,700
Operating lease, weighted average remaining lease term	4 years 8 months 12 days			4 years 8 months 12 days	6 years 11 months 4 days
Operating lease, weighted average discount rate, percent	5.95%			5.95%	6.23%
Impairment loss to operating lease right-of-use assets				$ 16,600
Waltham Leases
Leases [Line Items]
Expiration date			Jul. 30, 2030
Operating lease, existence of option to extend			true
Lease, option to extend				The Company has the option to renew the leased space for an additional one time period of five years with written notice from the Company. As of December 31, 2023, the Company has no reasonable certainty that this option to extend will be exercised.
Lease commencement month and year			2021-09
Additional one time lease period			5 years
Tenant improvement allowance to be reimbursed	$ 900		$ 3,100	$ 900
New Lease Agreement with BP Bay Colony LLC
Leases [Line Items]
ROU asset			6,000
Lease liability			6,000
Sublease with AMAG Pharmaceuticals
Leases [Line Items]
ROU asset			17,300
Lease liability			$ 17,300
2022 SOW Under the DMS Agreement
Leases [Line Items]
Lease expiration month and year		2024-12
ROU asset		$ 14,700
Lease liability		14,700
Reduction to right-of-use asset and lease liability	$ 4,900
Utilization fee		$ 16,300
Lessee operating lease, lease term including renewal option		2 years 3 months