Income Taxes - Additional Information (Details) - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Income Taxes [Line Items]
U.S. current income tax expense	$ (265,000)	$ 1,007,000
Increase in deferred tax assets valuation allowance	$ 35,406,000	22,268,000
Operating loss carryforwards carryback period	5 years
Percentage of TCJA limitations on net operating loss carryforwards to taxable income	80.00%
Uncertain tax positions	$ 0	0
Unrecognized tax benefits, interest and penalties accrued	$ 0	0
Earliest Tax Year
Income Taxes [Line Items]
Open tax year	2019
Latest Tax Year
Income Taxes [Line Items]
Open tax year	2022
Federal
Income Taxes [Line Items]
Operating loss carryforwards	$ 0	13,300,000
Federal | Research and Development
Income Taxes [Line Items]
Tax credit carryforwards	$ 6,600,000	2,800,000
Tax credit carryforwards expiration year	2040
Federal | Orphan Drug Credit (ODC)
Income Taxes [Line Items]
Tax credit carryforwards	$ 4,800,000
Tax credit carryforwards expiration year	2041
State
Income Taxes [Line Items]
Operating loss carryforwards	$ 3,600,000	8,500,000
Operating loss carryforwards expiration year	2035
State | Research and Development
Income Taxes [Line Items]
Tax credit carryforwards	$ 1,300,000	800,000
Tax credit carryforwards expiration year	2035
Foreign
Income Taxes [Line Items]
Operating loss carryforwards	$ 72,900,000	$ 16,800,000