CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Operating expenses:
Research and development	$ 118,870	$ 120,735
General and administrative	52,332	49,083
Total operating expenses	171,202	169,818
Loss from operations	(171,202)	(169,818)
Total other income (loss), net:
Interest income	1,876	1,315
Other income (loss), net	351	(2,452)
Loss before income taxes	(168,975)	(170,955)
Income tax (benefit) expense	(265)	1,007
Net loss	$ (168,710)	$ (171,962)
Net loss per share - basic	$ (2.20)	$ (2.74)
Net loss per share - diluted	$ (2.20)	$ (2.74)
Weighted-average common shares outstanding - basic	76,654,856	62,782,126
Weighted-average common shares outstanding - diluted	76,654,856	62,782,126
Comprehensive loss:
Net loss	$ (168,710)	$ (171,962)
Other comprehensive income (loss), net of tax:
Unrealized (loss) gain on available-for-sale securities	(313)	1
Foreign currency translation adjustment		(44)
Total other comprehensive loss	(313)	(43)
Comprehensive loss	$ (169,023)	$ (172,005)