X0306 4 2022-12-19 0001581280 Twist Bioscience Corp TWST 0001753655 Leproust Emily M. C/O TWIST BIOSCIENCE CORPORATION 681 GATEWAY BLVD. SOUTH SAN FRANCISCO CA 94080 true true false false Chief Executive Officer Common Stock 2022-12-19 4 A false 59758 0 A 239707 D Employee Stock Option (right to buy) 5.95 2025-09-28 Common Stock 0 24360 D Employee Stock Option (right to buy) 8.82 2027-09-28 Common Stock 0 150879 D Employee Stock Option (right to buy) 26.66 2028-11-18 Common Stock 0 266539 D Employee Stock Option (right to buy) 23.33 2029-10-23 Common Stock 0 131290 D Represents a restricted stock unit award ("RSU") of which 1/16th of the total number of RSUs vest on each quarterly anniversary of December 19, 2022 for a total vesting period of 48 months, subject to the Reporting Person's continuous service through each vesting date. The option is immediately exercisable. 25% of the shares subject to the option vested on September 1, 2016 and 1/48th of the shares subject to the option vest on each monthly anniversary thereafter, subject to the Reporting Person's continuous service through each vesting date. The option is immediately exercisable. 10% of the shares subject to the option vested on September 28, 2017, 15% of the shares subject to the option vested on September 28, 2018, and 1/48th of the shares subject to the option vest on each monthly anniversary thereafter, subject to the Reporting Person's continuous service through each vesting date. 20% of the shares subject to the option vested and became exercisable on October 31, 2019 and 1/60th of the shares subject to the option vest and become exercisable on each monthly anniversary thereafter, subject to the Reporting Person's continuous service through each vesting date. 25% of the shares subject to the option vested on October 24, 2020, and 1/48th of the shares subject to the option vest on each monthly anniversary thereafter, subject to the Reporting Person's continuous service through each vesting date. /s/ Alyssa Zhang, as Attorney-in-Fact for Emily M. Leproust 2022-12-19