X0306 4 2021-10-15 0 0000874015 IONIS PHARMACEUTICALS INC IONS 0001753652 Reikes Peter N 2855 GAZELLE COURT CARLSBAD CA 92010 1 0 0 0 Common Stock 2021-10-15 2021-10-15 4 M 0 1777 0.0 A 14222 D Restricted Stock Unit 0.0 2021-10-15 2021-10-15 4 M 0 1777 0.0 D Common Stock 1777 10664 D Acquired pursuant to vesting and release of shares in accordance with a Restricted Stock Unit award. Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value. Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid in whole shares of Ionis common stock or cash as may be determined by the Company. By: Patrick R. O'Neil, attorney-in-fact For: Peter N. Reikes 2021-10-19