X0306 4 2021-07-01 0 0000874015 IONIS PHARMACEUTICALS INC IONS 0001753652 Reikes Peter N 2855 GAZELLE COURT CARLSBAD CA 92010 1 0 0 0 Non-Qualified Stock Option (right to buy) 40.05 2021-07-01 2021-07-01 4 A 0 12000 0.0 A 2022-07-01 2031-06-30 Common Stock 12000 12000 D Restricted Stock Unit 0.0 2021-07-01 2021-07-01 4 A 0 5333 0.0 A Common Stock 5333 19552 D Grant of July 1, 2021 to reporting person of stock options under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. 100% of the shares subject to the option vest and become exercisable on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier. The option is exercisable to 0 shares on July 1, 2021. Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value. Grant of July 1, 2021 to reporting person of Restricted Stock Unit award under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. These Restricted Stock Units vest 100% on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier, and will be delivered to the reporting person on the July 15th following the vesting date. The Restricted Stock Unit is vested as to 0 shares on July 1, 2021. By: Patrick R. O'Neil, attorney-in-fact For: Peter N. Reikes 2021-07-06