X0306 4 2020-10-15 0000874015 IONIS PHARMACEUTICALS INC IONS 0001753652 Reikes Peter N C/O IONIS PHARMACEUTICALS, INC. 2855 GAZELLE COURT CARLSBAD CA 92010 1 0 0 0 Common Stock 2020-10-15 2020-10-15 4 M 0 1778 0 A 5334 D Restricted Stock Units 2020-10-15 2020-10-15 4 M 0 1778 0 D Common Stock 1778 3554 D Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards. Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value. These Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. /s/Patrick R. O'Neil, attorney-in-fact 2020-10-19