144 0001753537 XXXXXXXX LIVE 0001655759 Arvinas Inc 001-38672 395 Winchester Ave 5 Science Park New Haven CT 06511 475-345-3828 John G. Houston former President and CEO Director Common Morgan Stanley Smith Barney LLC

1 New York Plaza New York NY 100004

35297 466183.75 63960997 02/27/2026 NASDAQ Common 02/27/2026 Settlement of vested restricted stock units Arvinas, Inc N 35297 02/27/2026 Not applicable Y The sale reported on this Form 144 was made automatically to cover withholding taxes following the vesting of restricted stock units previously granted to Dr. Houston when Dr. Houston was serving as President and CEO. The sale does not represent a discretionary trade. 02/27/2026 /s/ Jared Freedberg, as attorney-in-fact for John G. Houston