X0306 4 2021-08-02 0 0001655759 ARVINAS, INC. ARVN 0001753537 Houston John G C/O ARVINAS, INC. 5 SCIENCE PARK, 395 WINCHESTER AVE. NEW HAVEN CT 06511 1 1 0 0 President and CEO Common Stock 2021-08-02 4 M 0 45922 16.00 A 873565 D Common Stock 2021-08-02 4 S 0 25143 96.96 D 848422 D Common Stock 2021-08-02 4 S 0 6992 97.66 D 841430 D Common Stock 2021-08-02 4 S 0 7600 98.86 D 833830 D Common Stock 2021-08-02 4 S 0 3441 99.96 D 830389 D Common Stock 2021-08-02 4 S 0 2746 100.66 D 827643 D Stock Option (right to buy) 16.00 2021-08-02 4 M 0 45922 0.00 D 2028-09-25 Common Stock 45922 42228 D The stock option exercise reported in this Form 4 was effected pursuant to a 10b5-1 trading plan adopted by the reporting person on December 30, 2020. The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 30, 2020. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $96.39 to $97.35, inclusive. The reporting person undertakes to provide to Arvinas, Inc., any security holder of Arvinas, Inc., or the staff at the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price range within the range set forth in this footnote (3). The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $97.39 to $97.97, inclusive. The reporting person undertakes to provide to Arvinas, Inc., any security holder of Arvinas, Inc., or the staff at the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price range within the range set forth in this footnote (4). The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $98.435 to $99.38, inclusive. The reporting person undertakes to provide to Arvinas, Inc., any security holder of Arvinas, Inc., or the staff at the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price range within the range set forth in this footnote (5). The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $99.45 to $100.375, inclusive. The reporting person undertakes to provide to Arvinas, Inc., any security holder of Arvinas, Inc., or the staff at the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price range within the range set forth in this footnote (6). The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $100.450 to $100.92, inclusive. The reporting person undertakes to provide to Arvinas, Inc., any security holder of Arvinas, Inc., or the staff at the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price range within the range set forth in this footnote (7). This option award was granted on September 26, 2018. 1/4 of the shares underlying the award vested as of January 5, 2018, with the remainder of the shares vesting in equal monthly installments following January 5, 2018 through January 5, 2021. /s/ Matthew Batters, as attorney-in-fact for John Houston 2021-08-04