X0306 4 2021-02-26 0 0001655759 ARVINAS, INC. ARVN 0001753537 Houston John G C/O ARVINAS, INC. 5 SCIENCE PARK, 395 WINCHESTER AVE. NEW HAVEN CT 06511 1 1 0 0 President and CEO Common Stock 817623 D Common Stock 2020-06-30 4 A 0 315 28.50 A 817938 D Common Stock 2020-12-31 4 A 0 310 29.02 A 818248 D Common Stock 2021-03-02 4 M 0 17510 A 835758 D Common Stock 2021-03-02 4 S 0 8115 77.4495 D 827643 D Stock Option (right to buy) 78.30 2021-02-26 4 A 0 219500 0.00 A 2031-02-25 Common Stock 219500 0 D Restricted Stock Units 2021-03-02 4 M 0 17510 0.00 D Common Stock 17510 35021 D On March 23, 2020, the reporting person filed a Form 4 that incorrectly disclosed the sale of shares of common stock to cover withholding taxes following the vesting of previously granted Restricted Stock Units. The correct number of shares sold was 5,542, not 5,405, reducing the number of securities beneficially owned by the reporting person by 137 shares. The shares were acquired under the 2018 Employee Stock Purchase Plan in transactions that were exempt under both Rule 16b-3(d) and Rule 16b-3(c). Includes 315 shares acquired under the 2018 Employee Stock Purchase Plan. Includes an aggregate of 625 shares acquired under the 2018 Employee Stock Purchase Plan. Each Restricted Stock Unit represents a contingent right to receive one share of the Issuer's common stock. This sale was made to cover withholding taxes following the vesting of previously granted Restricted Stock Units. The broker sold shares of the Issuer's common stock for certain employees following the vesting of previously granted Restricted Stock Units, including the common stock reported on this Form 4 by the reporting person, at an average price of $77.4495. This option award was granted on February 26, 2021. 1/4 of the shares underlying the award shall vest on February 26, 2022, with the remainder of the shares vesting in equal monthly installments following February 26, 2022 through February 26, 2025. On March 1, 2019, the reporting person was granted 70,042 Restricted Stock Units, vesting in four equal annual installments beginning March 1, 2020. /s/ Matthew Batters, as attorney-in-fact for John G. Houston 2021-03-02