X0306 4 2021-02-16 0 0001655759 ARVINAS, INC. ARVN 0001753537 Houston John G C/O ARVINAS, INC. 5 SCIENCE PARK, 395 WINCHESTER AVE. NEW HAVEN CT 06511 1 1 0 0 President and CEO Common Stock 2021-02-16 4 M 0 44000 16.00 A 860000 D Common Stock 2021-02-16 4 S 0 8928 77.6189 D 851272 D Common Stock 2021-02-16 4 S 0 21249 78.6568 D 830023 D Common Stock 2021-02-16 4 S 0 13223 79.7165 D 816800 D Common Stock 2021-02-16 4 S 0 600 80.25 D 816200 D Stock Option (right to buy) 16.00 2021-02-16 4 M 0 44000 0.00 D 2028-09-25 Common Stock 44000 88880 D The stock option exercise reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 30, 2020. The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 30, 2020. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $77.12 to $78.11, inclusive. The reporting person undertakes to provide to Arvinas, Inc., any security holder of Arvinas, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (3) through (6) to this Form 4. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $78.13 to $79.09, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $79.13 to $80.06, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $80.13 to $80.49, inclusive. This option award was granted on September 26, 2018. 1/4 of the shares underlying the award vested on March 31, 2019, with the remainder of the shares vesting in equal monthly installments following March 31, 2019 through March 31, 2022. /s/ Matthew Batters, as attorney-in-fact for John G Houston 2021-02-18