X0306 4 2019-01-18 0 0001655759 ARVINAS, INC. ARVN 0001753537 Houston John G C/O ARVINAS, INC. 5 SCIENCE PARK, 395 WINCHESTER AVE. NEW HAVEN CT 06511 1 1 0 0 President and CEO Stock Option (right to buy) 16.00 2019-01-18 4 A 0 13360 0.00 A 2019-01-18 2028-09-25 Common Stock 13360 13360 D On September 26, 2018, the reporting person was granted an option to purchase 13,360 shares of common stock, which was reported on Form 4 filed September 28, 2018. The option vests upon achievement of a regulatory milestone for the Issuer's androgen receptor program. On January 18, 2019, the compensation committee of the Issuer determined that the regulatory milestone was met, resulting in vesting of the option in full. /s/ Matthew Batters, as attorney-in-fact for John G. Houston 2019-01-23