X0306 4 2021-04-05 0 0001655759 ARVINAS, INC. ARVN 0001753281 Taylor Ian C/O ARVINAS, INC. 5 SCIENCE PARK, 395 WINCHESTER AVE. NEW HAVEN CT 06511 0 1 0 0 Chief Scientific Officer Common Stock 2021-04-05 4 M 0 25000 16.00 A 103645 D Common Stock 2021-04-05 4 S 0 4100 66.01 D 99545 D Common Stock 2021-04-05 4 S 0 16450 66.80 D 83095 D Common Stock 2021-04-05 4 S 0 4450 67.56 D 78645 D Stock Option (right to buy) 16.00 2021-04-05 4 M 0 9211 0.00 D 2028-09-25 Common Stock 9211 0 D Stock Option (right to buy) 16.00 2021-04-05 4 M 0 15789 0.00 D 2028-09-25 Common Stock 15789 28601 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 5, 2021. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $65.30 to $66.29, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the Staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within such range. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $66.31 to $67.30, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the Staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within such range. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $67.31 to $68.07, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the Staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within such range. This option award was granted on September 26, 2018. 1/4 of the shares underlying the award vested as of June 1, 2017, with the remainder of the shares vesting in equal monthly installments following June 1, 2017 through June 1, 2020. This option award was granted on September 26, 2018. 1/4 of the shares underlying the award vested on June 28, 2019, with the remainder of the shares vesting in equal monthly installments following June 28, 2019 through June 28, 2022. /s/ Matthew Batters as attorney-in-fact for Ian Taylor 2021-04-07